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ICD-10 Coding for Antiphospholipid Syndrome(D68.61)

Complete ICD-10-CM coding and documentation guide for Antiphospholipid Syndrome. Includes clinical validation requirements, documentation requirements, and coding pitfalls.

Also known as:

APSHughes Syndromeapls

Related ICD-10 Code Ranges

Complete code families applicable to Antiphospholipid Syndrome

D68.6-D68.69Primary Range

Other thrombophilia

This range includes antiphospholipid syndrome, which is a primary condition within this category.

Key Information: ICD-10 code for antiphospholipid syndrome

Essential facts and insights about Antiphospholipid Syndrome

The ICD-10 code for antiphospholipid syndrome is D68.61, used when confirmed with clinical and laboratory criteria.

Primary ICD-10-CM Code for antiphospholipid syndrome

Antiphospholipid syndrome
Billable Code

Decision Criteria

clinical Criteria

  • Confirmed APS with laboratory and clinical criteria

coding Criteria

  • Sequence underlying condition first if APS is secondary

Applicable To

  • Primary antiphospholipid syndrome
  • Secondary antiphospholipid syndrome

Excludes

  • Inherited thrombophilia (D68.5-)

Clinical Validation Requirements

  • Persistent lupus anticoagulant confirmed by two tests 12 weeks apart
  • Moderate-high titers of anticardiolipin or anti-β2GP1 antibodies

Code-Specific Risks

  • Misdiagnosis if lab criteria are not met
  • Incorrect coding if APS is secondary to another condition without proper sequencing

Coding Notes

  • Ensure proper documentation of lab results and clinical criteria for APS.

Ancillary Codes

Additional codes that should be used in conjunction with the main diagnosis codes when applicable.

Other specified diseases and conditions complicating pregnancy, childbirth, and the puerperium

O99.89
Use with D68.61 when APS complicates pregnancy.

Differential Codes

Alternative codes to consider when ruling out similar conditions to the primary diagnosis.

Primary thrombophilia

D68.5
Use D68.5 for inherited thrombophilia, not for APS.

Documentation & Coding Risks

Avoid these common documentation and coding issues when documenting Antiphospholipid Syndrome to ensure proper reimbursement, maintain compliance, and reduce audit risk. These guidelines are particularly important when using ICD-10 code D68.61.

Impact

Clinical: Potential misdiagnosis, Regulatory: Non-compliance with documentation standards, Financial: Claim denials due to insufficient documentation

Mitigation Strategy

Use structured templates, Verify lab results before documentation

Impact

Reimbursement: Incorrect coding may lead to denied claims., Compliance: Non-compliance with coding guidelines., Data Quality: Inaccurate clinical data representation.

Mitigation Strategy

Ensure lab tests confirm APS criteria before coding.

Impact

High risk of audit if APS is coded without documented lab criteria.

Mitigation Strategy

Ensure all lab results are documented and meet APS criteria.

Documentation errors, coding pitfalls, and audit risks are interconnected aspects of medical coding and billing. Addressing all three areas helps ensure accurate coding, optimal reimbursement, and regulatory compliance.

Frequently Asked Questions

Common questions about ICD-10 coding for Antiphospholipid Syndrome, with expert answers to help guide accurate code selection and documentation.

Documentation Templates for Antiphospholipid Syndrome

Use these documentation templates to ensure complete and accurate documentation for Antiphospholipid Syndrome. These templates include all required elements for proper coding and billing.

APS with recurrent thrombosis

Specialty: Hematology

Required Elements

  • Lab results with dates
  • Clinical events
  • Treatment plan

Example Documentation

Patient diagnosed with APS confirmed by persistent LA and aCL IgG >40 GPL units. Recurrent DVT managed with anticoagulation.

Examples: Poor vs. Good Documentation

Poor Documentation Example
Positive aPLs, history of clots.
Good Documentation Example
Persistent LA confirmed by dRVVT and SCT on 1/1/2025 and 4/1/2025; aCL IgG 52 GPL-U.
Explanation
The good example provides specific lab results and dates, meeting APS criteria.

Need help with ICD-10 coding for Antiphospholipid Syndrome? Ask your questions below.

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