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ICD-10 Coding for Chronic Myeloid Leukemia(C92.10, C92.11, C92.12)

Complete ICD-10-CM coding and documentation guide for Chronic Myeloid Leukemia. Includes clinical validation requirements, documentation requirements, and coding pitfalls.

Also known as:

CMLChronic Myelogenous LeukemiaChronic Granulocytic Leukemia

Related ICD-10 Code Ranges

Complete code families applicable to Chronic Myeloid Leukemia

C92.1-C92.12Primary Range

Chronic myeloid leukemia codes

This range covers all phases of chronic myeloid leukemia, including chronic, accelerated, and blast phases.

Code Comparison: When to Use Each Code

Compare key differences between these codes to ensure accurate selection

CodeDescriptionWhen to UseKey Documentation
C92.10Chronic myeloid leukemia, BCR/ABL-positive, in remissionUse when the patient is in remission with documented molecular response.
  • Major molecular response sustained for ≥12 months
  • Last 2 qPCR results showing ≤0.01% IS
C92.11Chronic myeloid leukemia, BCR/ABL-positive, in relapseUse when the patient shows evidence of relapse with rising BCR/ABL1 levels.
  • Two consecutive BCR/ABL1 IS results >0.1%
  • Peripheral blood blasts >15%
C92.12Chronic myeloid leukemia, BCR/ABL-positive, in accelerated phaseUse when the patient is in the accelerated phase with documented clinical features.
  • 10-19% blasts in PB/BM
  • Basophils ≥20%
  • Platelets <100k unrelated to therapy

Clinical Decision Support

Always review the patient's clinical documentation thoroughly. When in doubt, choose the more specific code and ensure documentation supports it.

Key Information: ICD-10 code for chronic myeloid leukemia

Essential facts and insights about Chronic Myeloid Leukemia

The ICD-10 code for chronic myeloid leukemia is C92.10 for remission, C92.11 for relapse, and C92.12 for accelerated phase.

Primary ICD-10-CM Codes for chronic myeloid leukaemia

Chronic myeloid leukemia, BCR/ABL-positive, in remission
Billable Code

Decision Criteria

clinical Criteria

  • Patient in major molecular response with sustained remission.

Applicable To

  • Chronic myeloid leukemia in major molecular response

Excludes

  • Chronic myeloid leukemia, BCR/ABL-positive, in relapse (C92.11)

Clinical Validation Requirements

  • Major molecular response sustained for ≥12 months
  • Last 2 qPCR results showing ≤0.01% IS

Code-Specific Risks

  • Incorrectly coding remission without proper molecular documentation.

Coding Notes

  • Ensure remission status is clearly documented with molecular evidence.

Differential Codes

Alternative codes to consider when ruling out similar conditions to the primary diagnosis.

Chronic myeloid leukemia, BCR/ABL-positive, in relapse

C92.11
Use C92.11 for patients with rising BCR/ABL1 transcripts or hematologic relapse.

Chronic myeloid leukemia, BCR/ABL-positive, in remission

C92.10
Use C92.10 for patients in remission with documented molecular response.

Documentation & Coding Risks

Avoid these common documentation and coding issues when documenting Chronic Myeloid Leukemia to ensure proper reimbursement, maintain compliance, and reduce audit risk. These guidelines are particularly important when using ICD-10 code C92.10.

Impact

Clinical: Leads to inappropriate treatment planning., Regulatory: Non-compliance with coding standards., Financial: Potential loss of reimbursement.

Mitigation Strategy

Always specify the phase of CML., Document molecular response.

Impact

Reimbursement: Incorrect phase coding can lead to reimbursement issues., Compliance: Non-compliance with coding guidelines., Data Quality: Impacts the accuracy of clinical data.

Mitigation Strategy

Always document and code the specific phase of CML.

Impact

Failure to document the phase of CML can lead to audit issues.

Mitigation Strategy

Implement phase-specific documentation templates.

Documentation errors, coding pitfalls, and audit risks are interconnected aspects of medical coding and billing. Addressing all three areas helps ensure accurate coding, optimal reimbursement, and regulatory compliance.

Frequently Asked Questions

Common questions about ICD-10 coding for Chronic Myeloid Leukemia, with expert answers to help guide accurate code selection and documentation.

Documentation Templates for Chronic Myeloid Leukemia

Use these documentation templates to ensure complete and accurate documentation for Chronic Myeloid Leukemia. These templates include all required elements for proper coding and billing.

Chronic phase CML in remission

Specialty: Oncology

Required Elements

  • Phase of CML
  • BCR/ABL1 IS %
  • TKI therapy details
  • Response criteria

Example Documentation

Patient with CML-CP in sustained MR4.5 (0.002% IS). Last BM: 1% blasts, no additional mutations. TKI adherence 98%. Plan: BCR/ABL1 q3mo.

Examples: Poor vs. Good Documentation

Poor Documentation Example
Patient has CML. Continue imatinib.
Good Documentation Example
Ph+ CML-CP (C92.10) in sustained MR4.5 (0.002% IS via QuantideX). Last BM 2/2025: 1% blasts, no additional mutations. TKI adherence 98% per pill count. Plan: BCR::ABL1 q3mo.
Explanation
The good example provides specific molecular response data and treatment adherence, which are crucial for accurate coding and reimbursement.

Need help with ICD-10 coding for Chronic Myeloid Leukemia? Ask your questions below.

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