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ICD-10 Coding for Hyperglycinemia(E72.51)

Complete ICD-10-CM coding and documentation guide for Hyperglycinemia. Includes clinical validation requirements, documentation requirements, and coding pitfalls.

Also known as:

Nonketotic HyperglycinemiaNKH

Related ICD-10 Code Ranges

Complete code families applicable to Hyperglycinemia

E70-E88Primary Range

Metabolic disorders

This range includes disorders of amino acid metabolism, including hyperglycinemia.

Key Information: ICD-10 code for nonketotic hyperglycinemia

Essential facts and insights about Hyperglycinemia

The ICD-10 code for nonketotic hyperglycinemia is E72.51.

Primary ICD-10-CM Code for hyperglycinemia

Nonketotic hyperglycinemia
Billable Code

Decision Criteria

clinical Criteria

  • CSF glycine >200 μmol/L and CSF/plasma ratio >0.08

documentation Criteria

  • Genetic testing confirming GLDC or AMT mutation

Applicable To

  • Nonketotic hyperglycinemia

Excludes

  • Ketotic hyperglycinemia

Clinical Validation Requirements

  • CSF glycine >200 μmol/L
  • CSF/plasma glycine ratio >0.08
  • Genetic confirmation (GLDC or AMT gene mutation)

Code-Specific Risks

  • Misclassification with ketotic hyperglycinemia
  • Inadequate documentation of genetic testing

Coding Notes

  • Ensure documentation specifies nonketotic type and includes genetic testing results.

Ancillary Codes

Additional codes that should be used in conjunction with the main diagnosis codes when applicable.

Other seizures

G40.89
Use for documenting seizures associated with NKH.

Unspecified lack of expected normal physiological development

R62.50
Use for documenting developmental delays in NKH.

Differential Codes

Alternative codes to consider when ruling out similar conditions to the primary diagnosis.

Classical phenylketonuria

E70.0
Plasma phenylalanine >1,200 μmol/L with normal glycine levels.

Maple syrup urine disease

E71.0
Elevated branched-chain amino acids in urine.

Documentation & Coding Risks

Avoid these common documentation and coding issues when documenting Hyperglycinemia to ensure proper reimbursement, maintain compliance, and reduce audit risk. These guidelines are particularly important when using ICD-10 code E72.51.

Impact

Clinical: May lead to misdiagnosis or inappropriate treatment., Regulatory: Non-compliance with documentation standards., Financial: Potential for denied claims due to insufficient documentation.

Mitigation Strategy

Ensure detailed documentation of CSF and plasma glycine levels., Include genetic testing results in patient records.

Impact

Reimbursement: Incorrect coding may lead to denied claims., Compliance: Non-compliance with ICD-10 coding standards., Data Quality: Inaccurate clinical data representation.

Mitigation Strategy

Use E72.51 with genetic confirmation for NKH.

Impact

Lack of genetic testing documentation for NKH.

Mitigation Strategy

Ensure all genetic test results are included in patient records.

Documentation errors, coding pitfalls, and audit risks are interconnected aspects of medical coding and billing. Addressing all three areas helps ensure accurate coding, optimal reimbursement, and regulatory compliance.

Frequently Asked Questions

Common questions about ICD-10 coding for Hyperglycinemia, with expert answers to help guide accurate code selection and documentation.

Documentation Templates for Hyperglycinemia

Use these documentation templates to ensure complete and accurate documentation for Hyperglycinemia. These templates include all required elements for proper coding and billing.

Neonatal diagnosis of NKH

Specialty: Neonatology

Required Elements

  • CSF glycine and plasma ratio
  • Genetic test results
  • Neurological examination findings

Example Documentation

Neonate with CSF glycine 280 μmol/L, plasma 90 μmol/L, ratio 0.11, GLDC mutation confirmed.

Examples: Poor vs. Good Documentation

Poor Documentation Example
Infant with elevated glycine.
Good Documentation Example
Neonate presents with apnea, hypotonia, CSF glycine 280 μmol/L, plasma 90 μmol/L, ratio 0.11, GLDC mutation confirmed.
Explanation
The good example provides specific clinical and genetic details necessary for accurate coding.

Need help with ICD-10 coding for Hyperglycinemia? Ask your questions below.

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