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ICD-10 Coding for Low-Density Lipoprotein(E78.01, E78.00)

Complete ICD-10-CM coding and documentation guide for Low-Density Lipoprotein. Includes clinical validation requirements, documentation requirements, and coding pitfalls.

Also known as:

LDLBad Cholesterol

Related ICD-10 Code Ranges

Complete code families applicable to Low-Density Lipoprotein

E78.0-E78.6Primary Range

Disorders of lipoprotein metabolism and other lipidemias

This range includes codes for hypercholesterolemia, hyperlipidemia, and related conditions, which are directly relevant to LDL management.

Code Comparison: When to Use Each Code

Compare key differences between these codes to ensure accurate selection

CodeDescriptionWhen to UseKey Documentation
E78.01Familial hypercholesterolemiaUse when familial hypercholesterolemia is confirmed by clinical and genetic criteria.
  • LDL-C ≥190 mg/dL
  • Family history of premature cardiovascular disease
  • Genetic testing confirming LDLR mutation
E78.00Pure hypercholesterolemia, unspecifiedUse when hypercholesterolemia is present but familial criteria are not met.
  • LDL-C >160 mg/dL without familial criteria

Clinical Decision Support

Always review the patient's clinical documentation thoroughly. When in doubt, choose the more specific code and ensure documentation supports it.

Key Information: ICD-10 code for high LDL

Essential facts and insights about Low-Density Lipoprotein

The ICD-10 code for high LDL, specifically familial hypercholesterolemia, is E78.01. For unspecified hypercholesterolemia, use E78.00.

Primary ICD-10-CM Codes for low-density lipoprotein

Familial hypercholesterolemia
Billable Code

Decision Criteria

clinical Criteria

  • LDL-C levels and family history

documentation Criteria

  • Genetic confirmation of LDLR mutation

Applicable To

  • Genetic hypercholesterolemia

Excludes

  • Secondary hyperlipidemia (E78.2)

Clinical Validation Requirements

  • LDL-C ≥190 mg/dL
  • Family history of premature cardiovascular disease
  • Genetic testing confirming LDLR mutation

Code-Specific Risks

  • Misclassification if genetic testing is not documented

Coding Notes

  • Ensure documentation includes genetic testing results if available.

Ancillary Codes

Additional codes that should be used in conjunction with the main diagnosis codes when applicable.

Long-term (current) use of lipid-lowering agents

Z79.4
Use to indicate ongoing statin therapy.

Differential Codes

Alternative codes to consider when ruling out similar conditions to the primary diagnosis.

Pure hypercholesterolemia, unspecified

E78.00
Use E78.00 when familial criteria are not met or genetic testing is not performed.

Familial hypercholesterolemia

E78.01
Use E78.01 if familial criteria are met.

Documentation & Coding Risks

Avoid these common documentation and coding issues when documenting Low-Density Lipoprotein to ensure proper reimbursement, maintain compliance, and reduce audit risk. These guidelines are particularly important when using ICD-10 code E78.01.

Impact

Clinical: Misdiagnosis risk, Regulatory: Non-compliance with coding guidelines, Financial: Potential claim denials

Mitigation Strategy

Ensure genetic testing results are included in patient records

Impact

Reimbursement: Potential underpayment due to lack of specificity, Compliance: Increased audit risk, Data Quality: Decreased accuracy in health records

Mitigation Strategy

Review patient history and lab results to select the most specific code.

Impact

Using unspecified codes when specific codes are applicable

Mitigation Strategy

Regular training on code specificity and documentation requirements

Documentation errors, coding pitfalls, and audit risks are interconnected aspects of medical coding and billing. Addressing all three areas helps ensure accurate coding, optimal reimbursement, and regulatory compliance.

Frequently Asked Questions

Common questions about ICD-10 coding for Low-Density Lipoprotein, with expert answers to help guide accurate code selection and documentation.

Documentation Templates for Low-Density Lipoprotein

Use these documentation templates to ensure complete and accurate documentation for Low-Density Lipoprotein. These templates include all required elements for proper coding and billing.

Familial hypercholesterolemia diagnosis

Specialty: Cardiology

Required Elements

  • LDL-C levels
  • Family history
  • Genetic testing results

Examples: Poor vs. Good Documentation

Poor Documentation Example
High cholesterol noted. Will start statin.
Good Documentation Example
Patient with LDL-C 212 mg/dL via direct assay, xanthomas on Achilles tendons, father with premature MI at age 48. Genetic testing confirms LDLR mutation.
Explanation
The good example provides specific LDL levels, family history, and genetic confirmation, supporting the diagnosis of familial hypercholesterolemia.

Need help with ICD-10 coding for Low-Density Lipoprotein? Ask your questions below.

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