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ICD-10 Coding for Multidrug-Resistant Organisms(A41.81, Z16.21)

Complete ICD-10-CM coding and documentation guide for Multidrug-Resistant Organisms. Includes clinical validation requirements, documentation requirements, and coding pitfalls.

Also known as:

MDROAntibiotic-Resistant Infections

Related ICD-10 Code Ranges

Complete code families applicable to Multidrug-Resistant Organisms

A41.81Primary Range

Sepsis due to vancomycin-resistant Enterococcus

Primary code for infections caused by vancomycin-resistant Enterococcus.

Resistance to antibiotics

Used to document antibiotic resistance as a secondary code.

Code Comparison: When to Use Each Code

Compare key differences between these codes to ensure accurate selection

CodeDescriptionWhen to UseKey Documentation
A41.81Sepsis due to vancomycin-resistant EnterococcusUse when sepsis is confirmed to be caused by vancomycin-resistant Enterococcus.
  • Positive blood culture for Enterococcus
  • Resistance to vancomycin confirmed
Z16.21Resistance to vancomycinUse as a secondary code when documenting vancomycin resistance.
  • Laboratory confirmation of vancomycin resistance

Clinical Decision Support

Always review the patient's clinical documentation thoroughly. When in doubt, choose the more specific code and ensure documentation supports it.

Key Information: ICD-10 code for MDRO

Essential facts and insights about Multidrug-Resistant Organisms

The ICD-10 code for MDRO varies; A41.81 is used for VRE sepsis.

Primary ICD-10-CM Codes for mdro

Sepsis due to vancomycin-resistant Enterococcus
Billable Code

Decision Criteria

clinical Criteria

  • Confirmed VRE infection with sepsis symptoms

Applicable To

  • VRE sepsis

Excludes

  • Sepsis due to other organisms

Clinical Validation Requirements

  • Positive blood culture for Enterococcus
  • Resistance to vancomycin confirmed

Code-Specific Risks

  • Incorrect sequencing with resistance codes

Coding Notes

  • Ensure proper sequencing: infection code first, followed by resistance code.

Ancillary Codes

Additional codes that should be used in conjunction with the main diagnosis codes when applicable.

Resistance to vancomycin

Z16.21
Use as a secondary code to indicate resistance.

Differential Codes

Alternative codes to consider when ruling out similar conditions to the primary diagnosis.

Sepsis, unspecified organism

A41.9
Use A41.81 when VRE is confirmed; otherwise, use A41.9.

Resistance to other antibiotics

Z16.29
Use Z16.29 for resistance to antibiotics other than vancomycin.

Documentation & Coding Risks

Avoid these common documentation and coding issues when documenting Multidrug-Resistant Organisms to ensure proper reimbursement, maintain compliance, and reduce audit risk. These guidelines are particularly important when using ICD-10 code A41.81.

Impact

Clinical: May lead to inappropriate treatment plans., Regulatory: Non-compliance with documentation standards., Financial: Potential claim denials.

Mitigation Strategy

Use specific organism and resistance details, Educate staff on documentation standards

Impact

Reimbursement: Incorrect sequencing can lead to denied claims., Compliance: Non-compliance with ICD-10 guidelines., Data Quality: Inaccurate clinical data representation.

Mitigation Strategy

Always sequence infection code before resistance code.

Impact

Incorrect sequencing of infection and resistance codes.

Mitigation Strategy

Regular training on ICD-10 guidelines.

Documentation errors, coding pitfalls, and audit risks are interconnected aspects of medical coding and billing. Addressing all three areas helps ensure accurate coding, optimal reimbursement, and regulatory compliance.

Frequently Asked Questions

Common questions about ICD-10 coding for Multidrug-Resistant Organisms, with expert answers to help guide accurate code selection and documentation.

Documentation Templates for Multidrug-Resistant Organisms

Use these documentation templates to ensure complete and accurate documentation for Multidrug-Resistant Organisms. These templates include all required elements for proper coding and billing.

MDRO Infection Documentation

Specialty: Infectious Disease

Required Elements

  • Organism identification
  • Resistance profile
  • Infection site
  • Laboratory confirmation

Example Documentation

Patient diagnosed with VRE sepsis, confirmed by blood culture. Resistance to vancomycin documented.

Examples: Poor vs. Good Documentation

Poor Documentation Example
Patient has MDRO.
Good Documentation Example
Patient has vancomycin-resistant Enterococcus sepsis, confirmed by blood culture.
Explanation
The good example provides specific organism and resistance details.

Need help with ICD-10 coding for Multidrug-Resistant Organisms? Ask your questions below.

Ask about any ICD-10 CM code, or paste a medical note

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