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ICD-10 Coding for Nitric Oxide(I27.0, P29.3)

Complete ICD-10-CM coding and documentation guide for Nitric Oxide. Includes clinical validation requirements, documentation requirements, and coding pitfalls.

Also known as:

NOInhaled Nitric OxideFeNO Testing

Related ICD-10 Code Ranges

Complete code families applicable to Nitric Oxide

I27-I27.9Primary Range

Pulmonary heart disease and diseases of pulmonary circulation

Includes conditions like pulmonary hypertension, which are primary indications for nitric oxide therapy.

Other cardiovascular disorders originating in the perinatal period

Includes persistent fetal circulation, a condition treated with inhaled nitric oxide in neonates.

Code Comparison: When to Use Each Code

Compare key differences between these codes to ensure accurate selection

CodeDescriptionWhen to UseKey Documentation
I27.0Primary pulmonary hypertensionUse when documenting primary pulmonary hypertension requiring nitric oxide therapy.
  • Echocardiographic evidence of pulmonary hypertension
  • Hypoxemia unresponsive to 100% O₂
P29.3Persistent fetal circulationUse for neonates with persistent fetal circulation treated with inhaled nitric oxide.
  • Oxygenation index (OI) ≥25
  • PaO₂ <60 mmHg on 100% FiO₂

Clinical Decision Support

Always review the patient's clinical documentation thoroughly. When in doubt, choose the more specific code and ensure documentation supports it.

Key Information: ICD-10 code for nitric oxide therapy

Essential facts and insights about Nitric Oxide

The ICD-10 code for nitric oxide therapy includes I27.0 for primary pulmonary hypertension and P29.3 for persistent fetal circulation.

Primary ICD-10-CM Codes for nitric oxide

Primary pulmonary hypertension
Billable Code

Decision Criteria

clinical Criteria

  • Echocardiographic evidence of pulmonary hypertension

Applicable To

  • Idiopathic pulmonary arterial hypertension

Excludes

  • Pulmonary hypertension due to left heart disease (I27.2)

Clinical Validation Requirements

  • Echocardiographic evidence of pulmonary hypertension
  • Hypoxemia unresponsive to 100% O₂

Code-Specific Risks

  • Ensure echocardiographic evidence is documented.
  • Avoid use if left heart disease is present.

Coding Notes

  • Ensure primary condition is documented before coding for nitric oxide therapy.

Ancillary Codes

Additional codes that should be used in conjunction with the main diagnosis codes when applicable.

Mouthpiece for nitric oxide testing

A4617
Use with CPT 95012 for FeNO testing.

Unclassified drugs

J3490
Use for inhaled nitric oxide therapy when no specific code exists.

Differential Codes

Alternative codes to consider when ruling out similar conditions to the primary diagnosis.

Pulmonary hypertension due to left heart disease

I27.2
Presence of left heart disease as the underlying cause.

Congenital diaphragmatic hernia

Q79.0
Presence of diaphragmatic hernia as the primary condition.

Documentation & Coding Risks

Avoid these common documentation and coding issues when documenting Nitric Oxide to ensure proper reimbursement, maintain compliance, and reduce audit risk. These guidelines are particularly important when using ICD-10 code I27.0.

Impact

Clinical: Misrepresentation of patient condition., Regulatory: Non-compliance with coding standards., Financial: Denial of claims and potential audits.

Mitigation Strategy

Use FeNO testing codes only for asthma-related diagnoses.

Impact

Reimbursement: Denial of claims leading to loss of revenue., Compliance: Non-compliance with coding guidelines., Data Quality: Inaccurate representation of services provided.

Mitigation Strategy

Always append modifier -25 to E&M codes when billing with CPT 95012.

Impact

Lack of documentation for oxygenation index and PaO₂ levels.

Mitigation Strategy

Ensure all clinical criteria are documented before billing.

Documentation errors, coding pitfalls, and audit risks are interconnected aspects of medical coding and billing. Addressing all three areas helps ensure accurate coding, optimal reimbursement, and regulatory compliance.

Frequently Asked Questions

Common questions about ICD-10 coding for Nitric Oxide, with expert answers to help guide accurate code selection and documentation.

Documentation Templates for Nitric Oxide

Use these documentation templates to ensure complete and accurate documentation for Nitric Oxide. These templates include all required elements for proper coding and billing.

FeNO Testing for Asthma Monitoring

Specialty: Pulmonology

Required Elements

  • FeNO level in ppb
  • Device used for testing
  • Clinical correlation with asthma management

Example Documentation

FeNO: 42 ppb (NIOX MINO®). FEV₁ 78% predicted. Action: Step-up ICS/LABA per GINA. Code: 95012 + J45.901

Examples: Poor vs. Good Documentation

Poor Documentation Example
Elevated FeNO
Good Documentation Example
FeNO 65 ppb via NIOX VERO®; correlates with uncontrolled asthma per GINA 2024
Explanation
The good example provides specific FeNO levels and device, correlating with clinical guidelines.

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