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ICD-10 Coding for Premature Ovarian Failure(E28.3, E28.31, E28.39)

Complete ICD-10-CM coding and documentation guide for Premature Ovarian Failure. Includes clinical validation requirements, documentation requirements, and coding pitfalls.

Also known as:

Primary Ovarian InsufficiencyPremature Menopause

Related ICD-10 Code Ranges

Complete code families applicable to Premature Ovarian Failure

E28.3-E28.39Primary Range

Disorders of ovarian function

This range includes codes for primary ovarian failure and its subtypes, which are directly related to premature ovarian failure.

Postprocedural ovarian failure

Used when ovarian failure is due to surgical or medical interventions, such as chemotherapy.

Code Comparison: When to Use Each Code

Compare key differences between these codes to ensure accurate selection

CodeDescriptionWhen to UseKey Documentation
E28.3Primary ovarian failureUse when ovarian failure is primary and not due to external interventions.
  • FSH >25 IU/L on two occasions at least 4 weeks apart
  • Exclusion of iatrogenic causes
E28.31Premature menopauseUse for idiopathic premature menopause.
  • Cessation of menstruation before age 40 without known cause
E28.39Other primary ovarian failureUse when specific etiology like autoimmune or genetic is identified.
  • FSH >25 IU/L with identified autoimmune or genetic cause

Clinical Decision Support

Always review the patient's clinical documentation thoroughly. When in doubt, choose the more specific code and ensure documentation supports it.

Key Information: ICD-10 code for premature ovarian failure

Essential facts and insights about Premature Ovarian Failure

The ICD-10 code for premature ovarian failure is E28.3. Use E28.31 for premature menopause and E28.39 for other specified causes.

Primary ICD-10-CM Codes for premature ovarian failure

Primary ovarian failure
Non-billable Code

Decision Criteria

clinical Criteria

  • FSH levels and exclusion of iatrogenic causes

coding Criteria

  • Avoid using with Turner syndrome

Applicable To

  • Primary ovarian insufficiency

Excludes

  • Postprocedural ovarian failure (E89.4)
  • Turner syndrome (Q96.-)

Clinical Validation Requirements

  • FSH >25 IU/L on two occasions at least 4 weeks apart
  • Exclusion of iatrogenic causes

Code-Specific Risks

  • Confusion with postprocedural ovarian failure
  • Incorrect use with Turner syndrome

Coding Notes

  • Ensure documentation of FSH levels and exclusion of other causes.

Ancillary Codes

Additional codes that should be used in conjunction with the main diagnosis codes when applicable.

Personal history of ovarian failure

Z87.42
Use for patients with resolved ovarian failure under monitoring.

Differential Codes

Alternative codes to consider when ruling out similar conditions to the primary diagnosis.

Postprocedural ovarian failure

E89.4
Use when ovarian failure is due to medical or surgical interventions.

Documentation & Coding Risks

Avoid these common documentation and coding issues when documenting Premature Ovarian Failure to ensure proper reimbursement, maintain compliance, and reduce audit risk. These guidelines are particularly important when using ICD-10 code E28.3.

Impact

Clinical: Misdiagnosis of primary ovarian failure., Regulatory: Non-compliance with ICD-10 guidelines., Financial: Potential claim denials.

Mitigation Strategy

Always verify and document the absence of surgical or medical interventions.

Impact

Reimbursement: Incorrect coding can lead to denied claims., Compliance: Non-compliance with coding guidelines., Data Quality: Inaccurate patient records.

Mitigation Strategy

Use E89.4 for postprocedural ovarian failure.

Impact

Lack of documented FSH levels can lead to audit issues.

Mitigation Strategy

Ensure FSH levels are documented in all relevant cases.

Documentation errors, coding pitfalls, and audit risks are interconnected aspects of medical coding and billing. Addressing all three areas helps ensure accurate coding, optimal reimbursement, and regulatory compliance.

Frequently Asked Questions

Common questions about ICD-10 coding for Premature Ovarian Failure, with expert answers to help guide accurate code selection and documentation.

Documentation Templates for Premature Ovarian Failure

Use these documentation templates to ensure complete and accurate documentation for Premature Ovarian Failure. These templates include all required elements for proper coding and billing.

Diagnosis of Primary Ovarian Failure

Specialty: Endocrinology

Required Elements

  • Patient age
  • FSH levels
  • Exclusion of iatrogenic causes

Examples: Poor vs. Good Documentation

Poor Documentation Example
Patient has ovarian dysfunction
Good Documentation Example
40yo female with secondary amenorrhea x6mo, FSH 52 IU/L (8/1/25) and 49 IU/L (9/15/25), transvaginal US shows AFC <5. Diagnosis: Primary ovarian failure, etiology under investigation (E28.39)
Explanation
The good example provides specific clinical details and diagnostic criteria.

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