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ICD-10 Coding for Trypsin Inhibitory Capacity Disorders(E88.01)

Complete ICD-10-CM coding and documentation guide for Trypsin Inhibitory Capacity Disorders. Includes clinical validation requirements, documentation requirements, and coding pitfalls.

Also known as:

TIC DisordersAlpha-1 Antitrypsin Deficiency

Related ICD-10 Code Ranges

Complete code families applicable to Trypsin Inhibitory Capacity Disorders

E88.0-E88.9Primary Range

Metabolic disorders

This range includes codes for metabolic disorders, specifically E88.01 for Alpha-1 Antitrypsin Deficiency, which is associated with trypsin inhibitory capacity issues.

Chronic obstructive pulmonary disease and related conditions

This range includes codes for COPD, which may be used as ancillary codes when AAT deficiency leads to pulmonary manifestations.

Other diseases of liver

This range includes codes for liver diseases, which may be used as ancillary codes when AAT deficiency leads to hepatic manifestations.

Key Information: ICD-10 code for trypsin inhibitory capacity

Essential facts and insights about Trypsin Inhibitory Capacity Disorders

The ICD-10 code for trypsin inhibitory capacity disorder is E88.01, related to Alpha-1 Antitrypsin Deficiency.

Primary ICD-10-CM Code for trypsin inhibitory capacity

Alpha-1 antitrypsin deficiency
Billable Code

Decision Criteria

clinical Criteria

  • Confirmed low serum AAT and TIC assay results.

documentation Criteria

  • Detailed lab results and genetic testing documentation.

Applicable To

  • Reduced trypsin inhibitory capacity

Excludes

  • Tic disorders (F95.-)

Clinical Validation Requirements

  • Serum AAT level <57 mg/dL
  • TIC assay <80% inhibition
  • Phenotyping showing ZZ/SZ alleles

Code-Specific Risks

  • Confusion with tic disorders
  • Inadequate documentation of TIC methodology

Coding Notes

  • Ensure documentation includes specific assay methods and genetic results.

Ancillary Codes

Additional codes that should be used in conjunction with the main diagnosis codes when applicable.

COPD with acute exacerbation

J44.1
Use when AAT deficiency leads to COPD exacerbations.

Other specified liver diseases

K76.89
Use when AAT deficiency leads to liver disease.

Differential Codes

Alternative codes to consider when ruling out similar conditions to the primary diagnosis.

Tourette syndrome

F95.2
Tourette syndrome is characterized by motor and vocal tics, unrelated to AAT deficiency.

Documentation & Coding Risks

Avoid these common documentation and coding issues when documenting Trypsin Inhibitory Capacity Disorders to ensure proper reimbursement, maintain compliance, and reduce audit risk. These guidelines are particularly important when using ICD-10 code E88.01.

Impact

Clinical: May lead to misdiagnosis., Regulatory: Non-compliance with coding standards., Financial: Potential for claim denials.

Mitigation Strategy

Use specific assay names in documentation., Ensure genetic testing results are included.

Impact

Reimbursement: Incorrect coding may lead to denied claims., Compliance: Misclassification can result in compliance issues., Data Quality: Data integrity is compromised with incorrect coding.

Mitigation Strategy

Ensure proper differentiation by confirming AAT deficiency through lab tests.

Impact

Inadequate documentation of TIC results can lead to audit issues.

Mitigation Strategy

Ensure all lab results and genetic testing are documented.

Documentation errors, coding pitfalls, and audit risks are interconnected aspects of medical coding and billing. Addressing all three areas helps ensure accurate coding, optimal reimbursement, and regulatory compliance.

Frequently Asked Questions

Common questions about ICD-10 coding for Trypsin Inhibitory Capacity Disorders, with expert answers to help guide accurate code selection and documentation.

Documentation Templates for Trypsin Inhibitory Capacity Disorders

Use these documentation templates to ensure complete and accurate documentation for Trypsin Inhibitory Capacity Disorders. These templates include all required elements for proper coding and billing.

Pulmonology Evaluation

Specialty: Pulmonology

Required Elements

  • TIC assay results
  • Serum AAT levels
  • Genetic testing results
  • Pulmonary function tests

Example Documentation

Patient presents with dyspnea and emphysema. TIC assay: 50% inhibition. Serum AAT: 45 mg/dL. Genetic testing: PiZZ phenotype. Plan: Augmentation therapy.

Examples: Poor vs. Good Documentation

Poor Documentation Example
Low AAT levels observed.
Good Documentation Example
AAT serum level 35 mg/dL via nephelometry; TIC assay shows 55% inhibition using BAPNA substrate; PiZZ phenotype confirmed.
Explanation
The good example provides specific lab results and genetic confirmation, supporting the diagnosis.

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